Healthcare facilities waste an estimated $14 billion annually on inefficient medical equipment management, with nurses spending up to 60 minutes per shift searching for lost equipment. This buyer’s guide compares every major RTLS technology — RFID, Wi-Fi, Ultra-Wideband, Infrared, and BLE 5.1 — and provides a structured vendor evaluation framework for hospital administrators and procurement teams. One documented health system in North Carolina saved $10 million annually after implementation.